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Research Article | DOI: https://doi.org/10.31579/2692-9406/011
*Corresponding Author: Fatimah Lateef, Senior Consultant, Dept of Emergency Medicine, Singapore General Hospital, Professor, Duke NUS Graduate Medical School Professor, Yong Loo Lin School of Medicine, National University of Singapore. Director, SingHealth Duke NUS Institute of
Citation: Lateef F, Sunny Chia S H, Alan Teo H B, Tan Teck C. (2020) The Evolving Demand for Negative Pressure Isolation Facilities during COVID 19: Trial of the Negative Pressure Isolation Tent. Biomedical Research and Clinical Reviews. 1(2); DOI: 10.31579/2692-9406/011
Copyright: ©2020 Fatimah Lateef, This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Received: 16 June 2020 | Accepted: 26 June 2020 | Published: 01 July 2020
Keywords: isolation; covid-19; negative pressure; smoke test; negative pressure tent
With COVID 19, more than ever before, healthcare institutions are realizing the need to develop, implement, assess, review and revise their infection control policies and guidelines of practice. In many facilities, patients who are known to be or suspected to be infectious are physically isolated from other patients and people. This is the rightful and ethical thing to do. These patients are usually identified through surveillance or using clinical and/ or microbiological criteria. Whilst practices such as personal and hand hygiene, safe infection control practices, distancing and others are useful, the use of formal isolation in hospitals represent an important step. This is also essential to reduce spread to healthcare workers.
In this paper, we describe a Negative Pressure Full Isolation Tent (NPFIT) which we tried out via simulation and the conduct of a simple smoke test to understand more on the concept of negative pressure and what it entails. It is our hope that readers will get a better understanding of this concept, through our simplified demonstration and trial.
COVID 19 posed multiple challenges in every sector, including healthcare, which is leading the operations during the pandemic. Healthcare workers are not immune to the infection, even as they lead the way in managing high numbers of patients. They too have to observe the necessary distancing, contact tracing and infection control measures which are implemented. At work, they have to adhere strictly to PPE (personal protective equipment) guidelines in managing patients. In many healthcare institutions, new, modular team-based rosters have been implemented to reduce cross-interaction between staff. [1,2] In fact, departments are also planning strategies in the event that they are faced with a situation whereby the whole team may have to be quarantined due to one or more members being affected or testing COVID 19 positive. [3, 4]
The issue of isolation and air filtration is proving to be a critical consideration for the health and safety of healthcare workers. With each infectious disease outbreak, it is becoming more apparent on the need to address this, as part of the general infection control measures. [2, 5] Today, isolation facilities are equipped with negative pressure rooms and wards. This is fast becoming a standard requirement in hospitals and healthcare institutions. Even Emergency Departments (EDs), which represent the frontline of the hospitals, are equipped with negative pressure rooms and resuscitation cubicles today. This has become an essential requirement in view that the infectious patients presenting to the ED are often undifferentiated. [3, 5, 6]
All about Negative Pressure
A negative pressure room refers to a volumetric space whereby the internal atmospheric pressure is lower than the spaces into which it will open. This negative pressure within isolation rooms will help to control the airflow so that the number of airborne infectious particles and bio-aerosols are reduced to a level which ensures cross-infection of other persons within the healthcare facility is unlikely. These isolation rooms must be very well-sealed in order to prevent excess air leakages into or out of the room. Preferably, the windows are those that do not open. The tighter the room is sealed, the better the differential pressure can be maintained.[2,5] The recommended pressure difference between these airborne infection isolation rooms and the corridor or the adjacent ambient pressure areas should be maintained at about 30Pa if the room has an ante-room and at 15 Pa, if the room does not have an ante-room. The air exchange rate recommended is at least 12 exchanges per hour. (5- 8)
In many general hospitals and healthcare facilities, only a certain percentage of their rooms are negative pressure rooms. As a result of this, many faced the need to come up with temporary negative pressure wards and rooms, at relatively short notice during this COVID 19 pandemic. Others found that they had to convert normal wards as well as even their standard positive pressure operating theatres into negative pressure environment, in order to accommodate the high numbers of patients during this pandemic. [9, 10] In general, these negative pressure isolation rooms are for patients who require droplet isolation, such as those with measles, varicella, tuberculosis, meningococcemia and of course, COVID 19.
Usually the numbers of isolation rooms required in an institution or healthcare facility is determined by several factors:
Besides these, looking at some trends and statistics is also pertinent:
The Prerequisites for Isolation Rooms
Isolation rooms require considerable resources to construct and maintain. The design goals must be clear from the conception phase. The idea is to be able to maintain an adequate level of infection protection in the environment surrounding the infectious patient. At the same time, it must be one of the prongs of the multiple strategies used to help reduce the threat to healthcare personnel entering the isolation rooms, as well as those outside the room. [2] Ventilation control is the key component of aerosol containment in the isolation rooms. Usually the ventilation engineer will work closely with the clinical team, Infectious Diseases physicians and the local infection control team in planning this. [6, 7]
The three factors which have to be monitored and looked into in this containment strategy are: [5, 7]
Often overlooked is the presence of stagnant and under-ventilated areas, where the infectious aerosols and materials can accumulate and concentrate. [5, 12, 13] Thus, these “dead spaces” must be a point to discuss with the engineering team.
Some isolation rooms have an ante-room and toileting facilities attached. It is essential to maintain negative pressure in the isolation room with respect to the ante-room, when the door is opened. Similarly, the ante-room must maintain a negative pressure with respect to the surrounding or the corridor, when the door is opened. Ante-rooms help to maintain pressure gradients and reduce the migration of infectious particles into the corridors. [11, 12, 13] Ante-rooms also provide a space for the staff to don and doff their PPE or disinfect devices. In short, it represents a ‘buffer zone’. The other important consideration is the air exchange rate (AER). This is a measure of how quickly contaminants can be removed from the area or zone. [13, 14] It is expressed as air exchange per hour (AE/Hr). The Total AER for an isolation room would then be guided by the formula:
Total AER = Ventilation exhaust flow from the Isolation Room
The Volume of the Isolation Room
Air distribution that are employed should be designed to provide high effective ventilation rates. The other consideration for these negative pressure isolation rooms would be leakages. These can be planned leakages (eg. gaps under the doors, unsealed sides or top of the doors) or unplanned leakages (eg. through electrical plumbing outlets, floor-wall and wall-ceiling joints). [14, 15]
The Need for Isolation Rooms
All the factors discussed above are important considerations in planning a healthcare facility today. Singapore General Hospital, the largest teaching institution and a tertiary referral centre in Singapore, is part of the Academic Medical Centre with Duke-NUS Graduate Medical School. The hospital has 1700 beds, 36 different specialties, including NeuroSurgery and Cardiothoracic Departments as well as the only Burns Centre and ICU in the region. At any point in time,between 24% to 30% of these are isolation beds, whether single or cohort isolation, with negative pressure set up. During the COVID 19 pandemic, we also had 50 container isolation rooms set up at a large open carpark for our use. In addition to our usual Intensive Care Unit (ICU) beds, we were able to prepare and mobilize a total of 200 ICU bed spaces, including converting 40 operating theatres for potential ICU patient utilization.
Besides this we also explored other choices, as a standby potential in the event we experienced overwhelming numbers of Covid 19 patients needing isolation. One of these was the use of a Negative Pressure Full Isolation Tent (NPFIT). The NPFIT can be assembled in about 30 minutes. Being mobile and movable, gives the NPFIT the flexibility to be deployed where it is needed, at a suitably chosen location or space. We set the NPFIT up for testing in our simulation laboratory. (Figures 1, 2)
The recommendation is to maintain the parameters within the “Standard” range. (Table 1, in red). However there is the option to increase the air velocity and number of air exchanges per hour, especially for patients who are deemed to be more infectious, or the super-spreaders, if they have been identified. With the NPFIT set-up, it was noted that the higher the setting for the air velocity, the noise generated is also higher as measured in decibels (Table 1). The adjustments can be done appropriately as needed in the real patient care situation. In some cases, at night during sleeping time the air velocity may be lowered to ensure the ‘noise’ is more bearable to the patient.
In testing the time to achieve the negative pressure build-up, a digital micro-manometer was used to measure the pressure differential inside the tent (X) and the atmosphere (Y) outside the tent. Each test was conducted in the manner to determine the time required for the negative enclosure to achieve the highest negative pressure, using the different modes. (See Schematic Diagram below). Point X is at 1.32 m from the side of the tent and taken at 1 m above the ground. Point Y is 1 m away from the tent, also at 1 m above ground
Table 2: Time taken to achieve negative pressure within the NPFIT
Following the completion of use of the tent for any one infectious patient, terminal cleaning has to be carried out before it is used on the next infectious patient. This is the same type of cleaning conducted for hospitals rooms, cubicles and bays in which an infectious patient has been placed. Simply put, it represents an intense disinfecting procedure that involves removing every detachable item for disinfection. Light fixtures, air ducts and all surfaces from the ceiling to the floor must also be disinfected. All this is done using the usual hospital grade disinfectant. The NPFIT represents an option which can be utilized, in the event we require extra negative pressure rooms during an infectious disease outbreak. It is also an option for institutions which are not equipped with negative pressure isolation rooms.
As we continue to learn more about infectious diseases, and also with the new and emerging infectious diseases, the need for negative pressure isolation facilities will only increase. Healthcare facilities and institutions must continue to develop, implement, assess, review and revise infection control policies and measures based on patients’ needs, infectious diseases characteristics and always bearing in mind, the threat of emerging new infectious agents and diseases. We must continue to develop innovation and capabilities in order to adequately prepare and be in control of a future outbreak or pandemic.
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